tman is right about the way Windows9x behaves with drives, i.e., bumping up the CD-ROM's letter when you add a second hard drive. There are utilities that are made for just the occasion when programs are left looking for drive E:, which is now drive F:. They will search for all references to drive E: in shortcuts, files, registry, etc. and change them to F: for you. Quick and easy.

The only one that comes to mind, however, is DriveMapper, from PowerQuest. It happens to come bundled with PartitionMagic. But I doubt you want to purchase the program simply for that ability. But, since PowerQuest thought of it, perhaps someone else has, too.

Edit: Darn, too slow again.