Power may be an issue as there's no connectors for desktop size drives. I also don't know if the on-board power supply can give enough juice to spin the big platters. Others here are _way_ more knowledgable than me and I'm sure can chime in. The only other thing I can think of is that there can be memory issues with large database sizes, but I think the kernel can handle 250 GB. Mark? Paul?

-Zeke