Generally, unsubscribing only works with reputable organizations.

I don't think a "donotspam" list analogous to the "donotcall" list will work, and would probably backfire, as there is no mechanism for stopping international spam and it gives spammers a ready-made list of addresses. (sigh)

I think we can hope for an opt-in only law (which will slow domestic spam) with no misleading routing allowed and with stiff penalties, or a whole new RFC for email to kill spam for anything but opt-in.

-jk