Quote:
The RTS and CTS shouldn't matter as on the RX, TX and ground are connected to the wideband serial connector.

That's not necessarily true. A null-modem, in addition to swapping RX and TX, loops back the RTS and CTS lines so that they're always on. If those pins aren't in the right place, you might never be getting the lines set properly on the empeg side, which means that the program might never be able to write or read from the port.
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Bitt Faulk