Cortisone is either amazing or useless.

I've had problems with my knees since high school (apparently wrestling and hockey are rough on your body, who knew?). The first time my orthopedic surgeon gave me Cortisone shots in my knees, they hurt like hell for two days (like they were on fire) and then it felt like somebody lubed my knees. It was glorious.

Now, 12 years and two surgeries later, Cortisone does nothing for me. I just get to wait for my shots of pig fluids (Orthovisc/Synvisc) every 9 months while waiting to get old enough for the Doc to replace my knees.

Good times!