OK, went out to the car and eveything worked fine - windows solution works again (i.e. reboot). First I thought "how embarassing" and then I thought I'd try playing with all the things I'd played with while I had it sitting on my desk. I managed to get it to not recognise "Cancel" again, but am not sure yet what is going it. I am guessing at Brickout or the calculator, but will have to have a bit more of a play to see. First comes some tea though ... Catch you later.
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(list 6284, Mk1 S/N 00299 4GB blue [sold]. Mk2 S/N 080000094 20GB blue)