Matt is absolutely correct about Logitech's positioning of the Harmony line. They bought the company to mainstream it back in 2004. Their intention was to drive the price down and offer a range from about $50 and currently up to many times that ($500+).

But, the software is a huge stumbling block. I gave one of my old Harmony models to a friend who is very much an average joe and he gave up on it within about a week. So instead he continues to use 4 or so different remotes. He's the kind of person that really needs something professionally set up by a custom installer, but there's no way he'd ever pay for it.

And yes, I currently have a number of URC products, but I'm using an MX-980 at the moment. I also own a few (4?) different Harmony remotes and two Philips Prontos.